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Urea

Urea is the principal nitrogenous waste product of metabolism and is generated from protein breakdown.

Urea is produced in the liver and almost exclusively excreted by the kidneys in urine. Urea, along with creatinine, are often the first tests used to check how well the kidneys are able to filter waste products from blood.

Uraemia indicates a high level of urea. Isolated raised levels may indicate renal dysfunction or dehydration.

Clinical Details
A raised urea level > 7.8 mmol/L is considered uraemia, and the following are usual causes of an increased serum urea:
  • Renal failure or disease (acute or chronic)
  • Dehydration due to low fluid intake, excessive fluid loss (vomiting, diarrhoea)
  • Excessive renal loss from diuretic use
  • Decreased renal perfusion causing low circulatory states: CCF, heart failure, severe hypotension, hypovolaemic shock
  • Gastrointestinal haemorrhage
  • Acute-on-chronic renal failure
  • High protein diet
  • Advancing age
  • Medications: corticosteroids, tetracyclines
  • Catabolic state resulting in tissue damage: from severe infection, post-major surgery, trauma, starvation states
Causes of low urea < 2.5mmol/L
  • Pregnancy low protein diet
  • excess water intake,
  • advanced liver disease (cirrhosis, liver failure)
Case Study
At Enfer Medical, we have integrated a cutting-edge and fully automated WASPLab® (Walk Away Specimen Processor) that has significantly enhanced our testing capabilities to ensure the highest of quality when processing patient samples.
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WASPLab® at Enfer Medical
Our entire microbiology workflow has been optimized using automation and highly sophisticated robots to ensure uninterrupted incubation for rapid bacterial growth and improved turnaround times for patients.
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Our Services

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Sample Type &
Volume Required

5mL venous serum or plasma

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Transporting
Samples

In addition to the packaging of samples, the transport/delivery of clinical samples to the laboratory is required to be in adherence to all national regulations for the safe transport of biological materials. Enfer Medical provides a fully compliant logistics service, aligned with clients’ testing requirements.

Prompt transport of specimens:
To ensure prompt testing of samples and release of results within the published test turnaround times, samples should arrive to the laboratory by 18:00. Test turnaround time is measured from receipt of the sample at the laboratory until the time the authorised results are reported to users.

Acceptance/Rejection
of Samples

In rare cases specimens may not be suitable for testing on arrival to the laboratory. In that case the sample will be rejected at the receipt stage and the service user will be notified immediately and an explanation as to why the sample could not be processed will be provided. Reasons why samples cannot be processed include but are not limited to:

  • Samples received beyond the stability limits and/or not at the correct temperature indicated for each test.
  • Incorrect sample type received.
  • Leaking samples, sample not received or sample insufficient for analysis as stated below within sample requirements.
  • Non-compliant samples or request forms i.e. those missing sample date information, missing sample test request and/or missing sample site/type information.
  • Samples received without the necessary patient identifiers.
Clients will be provided with guidance on Sample Receipt Anomalies.

Our Services

Service
Health & Wellness
General health and wellness testing can include a variety of tests, depending on the needs of the individual or recommendations of
Find Out More
Service
Sexual Health
Regular STI screening facilitates early treatment and reduces the long-term consequences of infection.
Find Out More
Service
Respiratory Health
Rapid early pathogen identification has important treatment and infection control implications. See our range of tests here.
Find Out More
Service
Reproductive & Female Health
Hormonal analysis is hugely beneficial to identifying problems that can arise during the reproductive years.
Find Out More
Service
All Services
View the full suite of services at Enfer Medical here.......
Find Out More
Result Values:

Quantitative results for Urea are reported in Numeric value in mmol/L. Please contact us for more information on the reference ranges used at Enfer Medical.

Critical results are communicated in accordance with the Communication of critical results for patients in the community- national laboratory handbook CSP041/2019

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